Patient-derived vascularized skin organoids unravel the role of systemic sclerosis fibroblasts in microvascular dysfunction.
Amandine Pitaval, Lara Jobeili, Caroline Welsch, Stéphanie Combe, Anastasia Papoz, Laure Gibot, Matthieu Roustit, Jean‐Luc Cracowski, Charles Coutton, Xavier Gidrol, Walid Rachidi
This study uses patient-derived vascularized skin organoids to show that SSc fibroblasts drive microvascular dysfunction through secretome-induced fibrotic responses and crosstalk with endothelial cells.
bioRxiv · Mar 28, 2026 · PreprintCell Biology