Xavier Gidrol

Space partitioning by self-organized epithelial networks

This study shows epithelial cells self-organize into reticulate networks, revealing a conserved mechanism for space partitioning through mechanical and topological dynamics.

Patient-derived vascularized skin organoids unravel the role of systemic sclerosis fibroblasts in microvascular dysfunction.

This study uses patient-derived vascularized skin organoids to show that SSc fibroblasts drive microvascular dysfunction through secretome-induced fibrotic responses and crosstalk with endothelial cells.

Human decellularized extracellular matrix from adipose tissue is a permissive microenvironment for pancreatic organoids generation

This study develops a decellularized adipose tissue-derived hydrogel (atdECM) that supports pancreatic organoid growth with improved transcriptional profiles compared to Matrigel.

Synthetic rescue of XPC phenotype via PIK3C3 downregulation

The paper identifies PIK3C3 downregulation as a potential therapeutic strategy to alleviate the photosensitive and DNA repair defects in XPC patients.

Detection of genes with differential expression dispersion unravels the role of autophagy in cancer progression

The paper evaluates methods to detect genes with differential expression dispersion in cancer datasets, identifying autophagy-related functions associated with tumor progression.