Walid Rachidi

Patient-derived vascularized skin organoids unravel the role of systemic sclerosis fibroblasts in microvascular dysfunction.

This study uses patient-derived vascularized skin organoids to show that SSc fibroblasts drive microvascular dysfunction through secretome-induced fibrotic responses and crosstalk with endothelial cells.

Type I Interferon Signaling Defines a Novel Disease Signature in Xeroderma Pigmentosum C Human Keratinocytes

This study identifies a type I interferon signaling signature in XPC-deficient keratinocytes, linking UVB exposure to JAK/STAT pathway dysregulation and hypersensitivity.

Generation and characterization of CRISPR-Cas9-Mediated XPC Gene Knockout in Human Skin Cells

This paper generates and characterizes CRISPR-Cas9-mediated XPC gene knockout in human skin cells to model XP-C disease and study its phenotypes and molecular mechanisms.

Synthetic rescue of XPC phenotype via PIK3C3 downregulation

The paper identifies PIK3C3 downregulation as a potential therapeutic strategy to alleviate the photosensitive and DNA repair defects in XPC patients.