The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
Erin McCaffrey, Alea C. Delmastro, Isobel Fitzhugh, Jolene S. Ranek, Sarah Douglas, Joshua M. Peters, Christine Camacho Fullaway, Marc MB Bosse, Candace C. Liu, Craig Gillen, Noah F. Greenwald, Sarah L. Anzick, Craig Martens, Seth Winfree, Yunhao Bai, , Michael Angelo
This study identifies hypoxia as a key driver of immune dysfunction in TB granulomas, correlating with bacterial persistence.
bioRxiv · Feb 18, 2025 · PreprintImmunology