Candace C. Liu

Transcriptional networks underlying tumour plasticity in small-cell lung cancer

This study identifies a novel intermediate cell state and a regulatory network in SCLC that drives lineage plasticity and immunogenicity.

Spatial proteomics reveals CD8+ T cell signatures and cellular niches associated with active HIV-1 replication in lymph nodes

Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence

This study analyzes multi-omic data from gliomas to identify therapeutic escape mechanisms and TME evolution, finding that N-glycosylation classifies tumor grade and immune transcriptome predicts GBM survival.

Automated classification of cellular expression in multiplexed imaging data with Nimbus

The paper introduces Nimbus, a deep learning model for predicting marker positivity in multiplexed imaging data using a pre-trained dataset, and shows its integration with clustering for cell subtype identification.

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

This study identifies hypoxia as a key driver of immune dysfunction in TB granulomas, correlating with bacterial persistence.

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition

The paper uses spatial imaging and computational analysis to identify features in metastatic tumors that predict response to immune checkpoint inhibition in TNBC patients.

IFNγ-Expressing Myeloid Cells Localize within Lipoproteinosis during Drug-Associated Pulmonary Alveolar Proteinosis occurring in Systemic Juvenile Idiopathic Arthritis

This study identifies IFNγ-expressing myeloid cells in lipoproteinosis regions of sJIA-daPAP patients, suggesting their role in immune pathology.

Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering

The paper introduces Pixie, a pipeline for robust pixel-level clustering in multiplexed imaging data to improve phenotyping and annotation across biological contexts.

Single-synapse analyses of Alzheimers disease implicate pathologic tau, DJ1, CD47, and ApoE

The paper analyzes synaptic molecular changes in Alzheimer's disease and related conditions using mass cytometry and imaging, identifying disease-specific molecular differences.