Scalable Production and Purification of Engineered ARRDC1-Mediated Microvesicles in a HEK293 Suspension Cell System
Kristin M. Luther, Ali Navaei, Leah Gens, Carson Semple, Pearl Moharil, Ilaria Passalacqua, Komal Vyas, Qiyu Wang, Shu‐Lin Liu, Lucy R. Sun, Senthil Ramaswamy, Davide Zocco, Joseph F. Nabhan
This study develops scalable methods to produce and purify engineered ARRDC1-mediated microvesicles (ARMMs) for gene therapy delivery, showing efficient production and in vivo biodistribution.
Scientific Reports · Mar 1, 2025Peer-reviewedBioengineering