Wen‐Ning Zhao

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

This paper engineers human-derived ARMMs for in vivo delivery of genome editing tools, showing efficient gene knockout and therapeutic potential in mouse models.

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.