Homeostatic Activation of 26S Proteasomes by Protein Kinase A Protects against Cardiac and Neurobehavior Malfunction in Alzheimer's Disease Mice
Anand Chakroborty, Saima Ejaz, Jack O. Sternburg, Yasin Asadi, Mingqi Cai, Abena Dwamena, Samiksha Giri, Oluwagbemisola Adeniji, Md Salim Ahammed, Erin Gilstrap, Md Giash Uddin, Cary S McDowell, Jinbao Liu, Hongmin Wang, Xuejun Wang
This study shows that homeostatic activation of 26S proteasomes by PKA protects against brain and cardiac dysfunction in Alzheimer's disease mice.
bioRxiv · Mar 28, 2025 · PreprintPhysiology