In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone Metabolome
Carolyn Chlebek, Casey McAndrews, Benjamin Aaronson, Hope D. Welhaven, Kanglun Yu, Samantha Costa, Joseph Shaver, Sophia Silvia, Victoria DeMambro, Ronald K. June, Meghan E. McGee‐Lawrence, Clifford james Rosen
This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.
Bone · Oct 28, 2025Peer-reviewedCell Biology