Ronald K. June

This study examines how mechanical injury alters metabolism in bovine and human chondrocytes, revealing differences in oxygen consumption and glutamine accumulation between healthy and osteoarthritic cells.

This study investigates how cyclical compression and shear deformations affect central metabolites in chondrocytes, showing changes in metabolites that could inform therapeutic mechanotransduction for cartilage repair.

This study develops a stoichiometric model of chondrocyte metabolism to examine how cyclical shear and compressive loading affect matrix protein synthesis, revealing sex-dependent differences and nitrogen limitations.

This study compares viscoelastic recovery time of chondrocytes from monolayer and alginate cultures, finding significant differences linked to pericellular matrix properties.

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

This study identifies sex-specific metabolic changes in injured joints of male and female mice using MALDI-MSI and metabolomics, revealing tissue-specific and spatially dependent metabolic signatures.

This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.

This study develops a 3D culture system for chondrocytes that supports pericellular matrix development and enables mechanotransduction studies through metabolomic profiling.

This study shows that high-fat diet worsens age-related loss of bone fracture toughness in C57BL/6JN mice.

This study shows that adenine-induced kidney disease in mice alters cortical bone metabolome, with sex-dependent differences in metabolic pathways.

This study identifies metabolic pathway changes in human lung carcinoma cells infected with SARS-CoV-2, linking them to productive or non-productive viral infection.

The paper examines how 18-months of diet, exercise, or combined interventions affect the serum metabolome of knee OA patients, revealing sex-specific metabolic changes.

This study examines metabolic changes in chondrocytes under simulated microgravity, finding metabolic shifts linked to early osteoarthritis.

This study compares metabolomic profiles of healthy and osteoarthritic human cartilage to identify disease-associated metabolic endotypes and pathways.

The paper measures thermal properties of agarose hydrogels and compares them to articular cartilage, finding similar thermal characteristics.

ECCO provides a Python UI for ensemble clustering and optimization on omics data, enabling efficient integration of advanced clustering methods.

This study identifies distinct metabolic phenotypes in human synovial fluid across osteoarthritis stages, revealing disease-specific metabolic pathways and potential biomarkers.

The paper shows that mechanical compression alters central metabolism in human chondrocytes, with grade IV osteoarthritic cells synthesizing amino acid precursors in response.