Author

Cassandra B. Klune

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Laura A. DeNardoiD· 4 shared Michael W. GongweriD· 4 shared Alexander S. EnosiD· 2 shared Caitlin M GoodpasteriD· 2 shared Meelan ShariiD· 2 shared Nico S. Jones· 2 shared Rita CheniD· 2 shared Adrienne Q. Kashay· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Laura A. DeNardoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRH+ glutamatergic neurons

Caitlin M Goodpaster, Zachary Zeidler, Michael W. Gongwer, Charles J Bland, Meelan Shari, Cassandra B. Klune, Nico S. Jones, Makayla Ramirez, Maryam Batul-Alturki, Rio Hundley, Jolie Utter, Laura A. DeNardo

This study shows that early adversity enhances prefrontal-amygdala communication via CRH+ glutamatergic neurons, leading to increased adolescent avoidance behavior.

bioRxiv · Sep 21, 2026 · PreprintNeuroscience

A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation

Michael W. Gongwer, Alex Qi, Alexander S. Enos, Sophia A. Rueda Mora, Sabahaddin Taha Solakoğlu, Russell N. Ahmed, Cassandra B. Klune, Meelan Shari, Adrienne Q. Kashay, Owen H. Williams, Aliza Hacking, Jack P. Riley, Gary A. Wilke, Yihong Yang, Hanbing Lu, , Scott A. Wilke

This study identifies a cell type-specific mechanism in the prefrontal cortex that underlies the rapid antidepressant effects of a specific rTMS protocol in a mouse model.

Cell · May 1, 2026Peer-reviewedNeuroscience

Developmentally distinct architectures in top-down circuits

Cassandra B. Klune, Caitlin M Goodpaster, Michael W. Gongwer, Christopher Gabriel, Rita Chen, Nico S. Jones, Lindsay A. Schwarz, Laura A. DeNardo

This study investigates how developmental changes in mPFC circuits influence behavioral strategies in juvenile, adolescent, and adult mice by manipulating and monitoring brain activity during threat responses.

bioRxiv · Aug 27, 2023 · PreprintNeuroscience

Brain-wide projections and differential encoding of prefrontal neuronal classes underlying learned and innate threat avoidance

Michael W. Gongwer, Cassandra B. Klune, João Couto, Benita Jin, Alexander S. Enos, Rita Chen, Drew Friedmann, Laura A. DeNardo

The paper maps brain-wide projections of mPFC neurons and identifies their specialized roles in threat avoidance using new computational tools.

Journal of Neuroscience · Jul 25, 2023Peer-reviewedNeuroscience