Drew Friedmann

Architecture of the Serotonergic Projectome in the Mouse Brain

Whole-brain axon tracing in 110 mouse brains divides raphe serotonin neurons into five projectomic groups, tied to transcriptome plus position and to dissociable behavioral effects of depletion.

Topographic structure and function of locus coeruleus norepinephrine neurons

The paper identifies topographic organization in locus coeruleus norepinephrine neurons, linking their morphology, gene expression, and activity to specific brain regions and learning-related behaviors.

Concerted modulation of spontaneous behavior and time-integrated whole-brain neuronal activity by serotonin receptors

The paper examines how serotonin receptor agonists and antagonists affect mouse behavior and whole-brain neuronal activity, revealing relationships between behavioral changes and Fos expression patterns.

Brain-wide projections and differential encoding of prefrontal neuronal classes underlying learned and innate threat avoidance

The paper maps brain-wide projections of mPFC neurons and identifies their specialized roles in threat avoidance using new computational tools.

Generation of a DAT-Flp mouse line for intersectional genetic targeting of dopamine neuron subpopulations

The paper introduces a DAT-Flp mouse line to selectively label dopaminergic subpopulations using intersectional genetic strategies.

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

The paper identifies a conserved cell type set in cerebellar nuclei across species and shows how it was duplicated to form new regions, with a shift in dominance in humans.

Mapping Mesoscale Axonal Projections in the Mouse Brain Using A 3D Convolutional Network

TrailMap is a 3D convolutional network that maps and quantifies axonal projections in cleared mouse brains, validated across multiple neuronal populations.

Serotonin Neurons in the Dorsal and Medial Raphe Nuclei: from Single-Cell Transcriptomes to Whole-Brain Projections

The paper characterizes serotonin neuron subtypes in the dorsal and medial raphe nuclei using single-cell RNA sequencing and maps their axonal projections to understand their functional diversity.

Temporal Evolution of Cortical Ensembles Promoting Remote Memory Retrieval

The paper uses TRAP2 to study how prefrontal cortex neurons involved in memory retrieval change over time and support remote memory.

Anatomical, Physiological, and Functional Heterogeneity of the Dorsal Raphe Serotonin System

This study identifies distinct sub-systems within the dorsal raphe serotonin system with different connectivity, physiological responses, and behavioral functions.