Author

Cassi Estrem

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Organism:C. elegans· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:electronic health records· 1 Assay:imaging· 1

Frequent Co-Authors

Steven W. FlavelliD· 4 shared Di Kang· 3 shared Eric BuenoiD· 3 shared Adam A. AtanasiD· 2 shared Jungsoo Kim· 2 shared Saba BaskoyluiD· 2 shared Sarah M. PuglieseiD· 2 shared Ziyu Wang· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Steven W. FlavellORCID

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4 papers

Recent·Most cited

Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state in C. elegans

Saba Baskoylu, Amit Kundra, Sarah M. Pugliese, Jungsoo Kim, Kamal Maher, Alex W. Hiser, Frank Meng, Cassi Estrem, Di Kang, Eric Bueno, Steven W. Flavell

The paper identifies parallel neural integrators in C. elegans that control distinct features of an aversive behavioral state by integrating sensory stimuli over different timescales.

bioRxiv · Jun 9, 2026 · PreprintNeuroscience

Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans

Cassi Estrem, Malvika Dua, Colby P. Fees, Gregory J. Hoeprich, Matthew B. Au, Bruce L. Goode, Lingyi Lynn Deng, Steven W. Flavell

The paper identifies bacterial signals that activate enteric sensory neurons in C. elegans and shows how pathogenic bacteria can block this activation.

Current Biology · Apr 20, 2026Peer-reviewedNeuroscience

Dissecting the Functional Organization of the C. elegans Serotonergic System at Whole-Brain Scale

Ugur Dag, Ijeoma Nwabudike, Di Kang, Matthew A. Gomes, Jung Soo Kim, Adam A. Atanas, Eric Bueno, Cassi Estrem, Sarah M. Pugliese, Ziyu Wang, Emma K. Towlson, Steven W. Flavell

The paper investigates how serotonin release from a specific neuron in C. elegans affects whole-brain activity and behavior by identifying core and interacting serotonin receptors and mapping their expression and functional roles.

Cell · May 15, 2023Peer-reviewedNeuroscience

Brain-wide representations of behavior spanning multiple timescales and states in C. elegans

Adam A. Atanas, Jungsoo Kim, Ziyu Wang, Eric Bueno, McCoy R. Becker, Di Kang, Jungyeon Park, Cassi Estrem, Talya S Kramer, Saba Baskoylu, Vikash K. Mansingkha, Steven W. Flavell

The paper maps how neuron classes in C. elegans encode behavior across different states and timescales using brain-wide activity recordings and probabilistic models.

bioRxiv · Nov 11, 2022 · PreprintNeuroscience