Farnesyl Transferase Inhibition for the Treatment of Tauopathies
Israel Hernández, Gabriel Luna, Jennifer N. Rauch, Michel Giroux, Celeste M M. Karch, Daniel Boctor, Nadia J Storm, Antonio Díaz, Cezary Żekanowski, Alexander A. Kang, Cassidy Hinman, Vesna Cerovac, Elmer Guzman, Hongjun Zhou, Alison Goate, , Kenneth S. Kosik
Lonafarnib reduces tau pathology in a tauopathy mouse model by targeting Rhes to enhance lysosomal degradation.
bioRxiv · Dec 18, 2018 · PreprintNeuroscience