Kenneth S. Kosik

This study identifies small-molecule inhibitors of the tau-LRP1 interaction using biochemical assays and high-throughput screening, showing reduced tau uptake in cellular assays.

This study investigates how 7q11.23 copy number variations disrupt brain organoid development, showing structural and functional abnormalities in neural circuits and spine morphology.

This study uses persistent homology to analyze neural activity in brain organoids and finds structured topological features at the scale of typical recordings.

SpikeLab is a text-to-analysis framework for neural spike data that ensures correct and reproducible results using agentic systems, outperforming other models in a controlled benchmark.

This paper identifies I-PDBs as BAG2-driven organelles that link proteostasis to CD8+ T cell surveillance by processing pathological tau into antigenic peptides.

The paper develops a recurrent neural network model to explain chronic pain development and recovery, showing that calming stimuli can reduce pain without pharmacological intervention.

The paper systematically analyzes RhoGAP expression and function in Drosophila border cell morphology and migration, showing most RhoGAPs are expressed and functionally required.

This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.

This study investigates ketamine's effects on human brain organoids, finding acute network silencing and chronic tolerance with reduced connectivity.

This study identifies genetic variants associated with Alzheimer's disease and frontotemporal dementia in admixed Latin American populations using whole-genome sequencing and ancestry analysis.

This paper presents a high-bandwidth, wireless brain-computer interface device capable of chronic recordings in animals, demonstrating reliable performance over weeks.

This study shows that structured firing sequences emerge in human and murine brain organoids and neonatal brain slices, suggesting innate rather than experience-dependent neural coding.

The paper develops epigenetic clocks using long-read DNA methylation data from diverse ancestries, showing improved aging predictions and identifying ancestry-specific aging pathways.

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

RT-Sort detects and sorts action potentials in real time with millisecond latencies using propagation patterns and a convolutional neural network.

The paper designs a 19-residue peptide that selectively induces aggregation of 4R tau over 3R tau, revealing structural and amino acid determinants of tauopathy propagation.

This study investigates the role of SUMO2/3 modification in mitigating Tau-induced synaptic and cognitive dysfunction in disease models.

This study uses high-density electrode arrays to analyze neural activity in human brain organoids, revealing functional connectivity patterns and responses to benzodiazepine treatment.

This paper introduces an automated method to detect extracellular action potentials from individual neurons, insensitive to waveform changes, enabling high-content screening with MEAs.

This paper describes an in vitro method to self-organize a human neural tube using geometric constraints, showing that neural and epidermal tissues are sufficient for morphogenesis.

This paper presents a scalable, easy-to-deploy protocol for detecting SARS-CoV-2 genetic material using Cas13-based technology paired with PCR and low-cost instrumentation.

PEARL is a fast, low-cost method for isolating RNA, DNA, and proteins to detect SARS-CoV-2 without commercial kits.

The paper identifies the proline-rich domain (PRD) of tau as a driver of liquid-liquid phase separation (LLPS) in cells, showing its phosphorylation-dependent behavior and interaction with microtubules.

Lonafarnib reduces tau pathology in a tauopathy mouse model by targeting Rhes to enhance lysosomal degradation.

The paper investigates how miRNA-mRNA networks regulate cell-type-specific transcriptomes during human brain development using AGO2-HITS-CLIP, single-cell profiling, and bipartite network analysis.

The paper identifies 6-O-sulfation on heparan sulfate proteoglycans as critical for tau internalization and shows it regulates uptake in multiple cell models.

This paper demonstrates the use of multi-electrode arrays to record action potential propagation in single axons, revealing insights into axonal physiology and excitability changes over time.

MEA Viewer provides a high-performance interactive tool for visualizing electrophysiological data from multi-electrode arrays, enabling direct visualization of action potential propagation.