A stable subgenomic reporter coronavirus enables transcriptional profiling of bystander cells.
Ciarán Gilbride, Joe Hemsley-Taylor, Catarina Nunes, Rebecca Penn, James Boot, Nima Pieris, Rupa Tripathy, Ziyi Yang, Matthew Hutchinson, Olivia K. Platt, Rachel Ulferts, Richard Mitter, Molly Strom, Nuno Brito Santos, David L.V. Bauer, Harriet V Mears
This paper develops a stable reporter coronavirus for studying transcriptional responses in infected and bystander cells, finding that infection primarily triggers inflammatory rather than interferon-mediated host responses.
Journal of General Virology · Jun 16, 2026Peer-reviewedMicrobiology