Richard Mitter

The paper identifies a direct interaction between Integrator and NELF that regulates transcriptional pausing and premature termination.

This paper develops a stable reporter coronavirus for studying transcriptional responses in infected and bystander cells, finding that infection primarily triggers inflammatory rather than interferon-mediated host responses.

The paper shows that a truncated ASH2L isoform, generated via a lineage-specific retrotransposon, primes developmental gene promoters during pluripotency and is required for later developmental transitions.

The paper introduces TT-TSS-seq, a method to map and quantify transcription start sites from nascent transcripts, revealing multiple initiation sites per gene and detecting unstable transcripts.

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

This study identifies STK19 as a factor facilitating the transition from initial TCR complex assembly to downstream repair steps by enabling RNAPII clearance.

The paper investigates FOXL2's role in ovarian development through multi-omics analysis, identifying its binding partners and regulatory targets, and shows that USP7 deletion causes infertility.

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

This study generates and characterizes human pre-neural spinal cord progenitors that can self-renew and differentiate into neural crest cells while adopting rostrocaudal identities.

The paper identifies how SETX mutations cause genome instability in AOA2 by increasing transcription stress and impairing repair mechanisms.

This study creates a single-cell transcriptome atlas of the developing zebrafish hindbrain, identifying markers and regulators of neurogenesis and cell differentiation.

The paper identifies Greb1 as essential for axial elongation and segmentation in vertebrate embryos, showing its role in maintaining axial progenitors and regulating the segmentation clock.