Author

James Boot

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Abdullah Abdullah· 1 shared Adele AlagiaiD· 1 shared Arianna Di FazioiD· 1 shared Catarina Nunes· 1 shared Ciarán GilbrideiD· 1 shared David L.V. BaueriD· 1 shared Federica BattistiniiD· 1 shared Harriet V MearsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Abdullah Abdullah

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2 papers

Recent·Most cited

Structural and functional basis of the non-canonical human Dicer-tRNA complex

Arianna Di Fazio, Stephan Hirschi, Federica Battistini, Nuno Santos, James Boot, Kamal Ajit, Abdullah Abdullah, Adele Alagia, Modesto Orozco, Monika Gullerová

The paper reveals the structural basis of hDicer-tRNA complex formation and shows that m5C modification facilitates tRNA cleavage by hDicer.

bioRxiv · Aug 17, 2026 · PreprintMolecular Biology

A stable subgenomic reporter coronavirus enables transcriptional profiling of bystander cells.

Ciarán Gilbride, Joe Hemsley-Taylor, Catarina Nunes, Rebecca Penn, James Boot, Nima Pieris, Rupa Tripathy, Ziyi Yang, Matthew Hutchinson, Olivia K. Platt, Rachel Ulferts, Richard Mitter, Molly Strom, Nuno Brito Santos, David L.V. Bauer, Harriet V Mears

This paper develops a stable reporter coronavirus for studying transcriptional responses in infected and bystander cells, finding that infection primarily triggers inflammatory rather than interferon-mediated host responses.

Journal of General Virology · Jun 16, 2026Peer-reviewedMicrobiology