Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells
Alex Mabry, Catherine E. Kuzmicki, Angelina O’Brien, Leonard B. Maggi, Jason D. Weber
The paper shows that loss of p53 and ARF increases type I interferon signaling, which drives proliferation and is inhibited by JAK1 inhibitors in tumor cells.
Molecular and Cellular Biology · May 12, 2025Peer-reviewedCancer Biology