The paper estimates circadian phases in human brain cells using single-nucleus RNA sequencing and finds disrupted ribosomal rhythms in Alzheimer's patients.

Neuron · Aug 6, 2025Peer-reviewedBioinformatics

Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells

Alex Mabry, Catherine E. Kuzmicki, Angelina O’Brien, Leonard B. Maggi, Jason D. Weber

The paper shows that loss of p53 and ARF increases type I interferon signaling, which drives proliferation and is inhibited by JAK1 inhibitors in tumor cells.

Molecular and Cellular Biology · May 12, 2025Peer-reviewedCancer Biology

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity

Che-Pei Kung, Nick Terzich, Ma Xenia G. Ilagan, Michael J. Prinsen, Madhurima Kaushal, Raleigh D. Kladney, J. Weber, Alex Mabry, Luisangely Soto Torres, Emily R. Bramel, Eric C. Freeman, Thwisha Sabloak, Sua Ryu, William M. Weber, Kyle A. Cottrell, , Jason D. Weber

This study shows ADAR1 protects TNBC cells from ferroptosis by regulating lipid composition, and identifies cobimetinib as a potential therapeutic agent when combined with ADAR1 loss.

bioRxiv · Jan 16, 2025 · PreprintCancer Biology

Activation of PKR by a short-hairpin RNA

Kyle A. Cottrell, Sua Ryu, Helen Donelick, Hung Mai, Addison A. Young, Jackson R. Pierce, Brenda Bass, Jason D. Weber

This study shows that an shRNA targeting DDX54 can activate PKR through a dsRNA-mediated mechanism, highlighting the need for careful validation of gene function.

Scientific Reports · Oct 9, 2024Peer-reviewedMolecular Biology

Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells

Kyle A. Cottrell, Sua Ryu, Jackson R. Pierce, Luisangely Soto Torres, Holly E. Bohlin, Angela M. Schab, Jason D. Weber

The paper shows that loss of DHX9 and ADAR1 in breast cancer cells activates dsRNA sensing pathways, leading to a viral mimicry phenotype.

Cancer Research Communications · Mar 26, 2024Peer-reviewedMolecular Biology