TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons
William McGuinness, Brent James Ryan, Catherine L. Guardado, Philippa Carling, Benjamin Vallin, Maria Claudia Caiazza, Rachel Heon‐Roberts, Peter Kilfeather, James Wantling, Johanna Hoffmann, Daniel R. Aird, Kenneth Lofstromm, Mei Zhang, Sally A. Cowley, Warren D. Hirst, Richard Wade‐Martins
The paper examines TFEB and TFE3 expression and function in brain cells, showing TFEB is restricted to glia while TFE3 is widespread, with distinct roles in mitochondrial and lysosomal biogenesis in neurons.
bioRxiv · Apr 22, 2025 · PreprintCell Biology