Maria Claudia Caiazza

Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading

The paper investigates dopamine release defects in Parkinson's patient-derived neurons and identifies reduced VMAT2 function as the cause.

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides

This study shows that SARM1 activation causes mitochondrial dysfunction in human neurons, which can be reversed by nicotinamide or prevented by antisense oligonucleotides.

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons

The paper examines TFEB and TFE3 expression and function in brain cells, showing TFEB is restricted to glia while TFE3 is widespread, with distinct roles in mitochondrial and lysosomal biogenesis in neurons.

Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson's GBA-N370S mutation

This study shows that the GBA-N370S mutation causes early hyperexcitability in striatal neurons by reducing sodium and potassium currents, which can be mitigated by aging or PKA antagonism.

Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging and disease

The paper profiles spatial transcriptomic and translatomic data of dopaminergic neurons in young and old mice, identifying markers of aging and disease-related pathways, and highlights CASR as a novel regulator of dopaminergic calcium handling.

A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

Nuclear Tau modulates VGluT1 expression: a new function for Tau

The paper shows that nuclear Tau regulates VGluT1 expression, linking Tau's non-canonical function to glutamatergic synaptic transmission and neurodegeneration.