Author

William McGuinness

University of OxfordORCID 0009-0002-1222-8224Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Brent James RyaniD· 4 shared Richard Wade‐MartinsiD· 4 shared Maria Claudia CaiazzaiD· 3 shared Rachel Heon‐RobertsiD· 3 shared Sally A. CowleyiD· 3 shared Jack P. ConnoriD· 2 shared Jane VowlesiD· 2 shared Janine BrandesiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Brent James RyanORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 1, 2026

Phenotypic screening in Parkinson's iPSC-dopamine neurons identifies the FASN-SREBP1 axis as a potential therapeutic target

Maria Claudia Caiazza, Janine Brandes, Elizabeth R. Barrow…·Richard Wade‐Martins

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

DOI 10.64898/2026.10.27.761977

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintApr 22, 2025

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons

William McGuinness, Brent James Ryan, Catherine L. Guardado…·Richard Wade‐Martins

The paper examines TFEB and TFE3 expression and function in brain cells, showing TFEB is restricted to glia while TFE3 is widespread, with distinct roles in mitochondrial and lysosomal biogenesis in neurons.

DOI 10.1101/2025.04.22.649949

humanmouse

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NeurosciencebioRxivPreprintFeb 3, 2025

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

Matthew G Williamson, Rachel Heon‐Roberts, Sarah N. J. Franks…·Brent James Ryan

This study shows USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms, enhancing mitophagy and mitochondrial efficiency in neurons.

2 citations

humanexperimental assay

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NeuroscienceCell ReportsPeer-reviewedMar 1, 2023

A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons

Helle Bogetofte, Brent James Ryan, Pia Jensen…·Richard Wade‐Martins

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

47 citationstop 1%

humanproteomics

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