In vitro-reconstituted Drosophila Arc capsids deliver gene editors to dystrophic muscle
Blake Lash, Daniel Strebinger, Michael Segel, Chau-Duy-Tam Vo, Katherine DeLong, Julie Pham, Charles Swan, Pradeep Kumar, Yugang Zhang, Catherine Liu, Joanie Mok, Rhiannon K. Macrae, Feng Zhang
This paper demonstrates the use of in vitro-assembled Drosophila Arc1 capsids to deliver gene editors to dystrophic muscle, achieving exon skipping and dystrophin restoration in mdx mice.
bioRxiv · May 25, 2026 · PreprintMolecular Biology