Michael Segel

This paper demonstrates the use of in vitro-assembled Drosophila Arc1 capsids to deliver gene editors to dystrophic muscle, achieving exon skipping and dystrophin restoration in mdx mice.

The paper identifies a human supergene region containing BRCA1, CCDC200, and U2 snRNAs, showing linkage disequilibrium and balancing selection across populations.

The paper profiles gene expression in human microglia from 141 patients, identifies population shifts in acute brain injury, maps eQTLs, and fine-maps Alzheimer's risk variants using hIPSC-derived macrophages.

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.