Single-Cell Sequencing Reveals Extensive Genetic Diversity Underlying Pediatric ALL Treatment Complexity
Yakun Pang, Tamara Prieto, Veronica Gonzalez-Pena, Athena Aragon, Yuntao Xia, Sheng Kao, Srinivas Rajagopalan, John Zinno, Jean Quentin, Julien Laval, Dennis J. Yuan, Nathaniel D. Omans, Catherine Potenski, David Klein, Matthew J. MacKay, , Charles Gawad
The paper uses single-cell sequencing to uncover hidden genetic diversity in pediatric ALL that is not detected by bulk sequencing, identifying treatment-resistant clones and their associated mutations.
bioRxiv · Mar 19, 2025 · PreprintCancer Biology