Yakun Pang

The paper uses single-cell sequencing to uncover hidden genetic diversity in pediatric ALL that is not detected by bulk sequencing, identifying treatment-resistant clones and their associated mutations.

This paper introduces PTA, a new WGA method that improves variant calling accuracy in single cells, enabling studies of genetic diversity and CRISPR off-target effects.

The paper constructs a single-cell atlas of hematopoiesis and leukemogenesis, identifies leukemia subpopulations, and develops a composite index to predict clinical outcomes.

LCA identifies subtle cell population diversity in large-scale single-cell RNA-seq data using a dual-space model with spectral clustering and technical variation control.