Trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apolipoprotein E co-pathologies
Breanna R. Dooling, Anne Vielle, Esteban Lucero, Catherine Rydland, Daphne Quang, Rose Summers, Hector Esquer, Christina M. Coughlan, Matthew D. Galbraith, Joaquin Maximiliano Espinosa, Daniel V. LaBarbera, Heidi J. Chial, Huntington Potter, Aurélie Ledreux, Noah R. Johnson
This study shows that trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apoE co-pathologies, with apoE playing a key role in the disease process.
bioRxiv · Jul 7, 2026 · PreprintNeuroscience