Spatial lung niches shape Pseudomonas aeruginosa persistence
Cecilia Katunge Kyanya, Duy Pham, Nana-Jane Chipampe, Phumrapee Boonklang, Louise Ellison, Andrew J. Balmer, Catherine Tudor, Jasmine Halliwell, Hon Man Chan, Vanessa Bonita Pereira, Benjamin M. Rumney, Holly Anderson, Shevaniee Umamaheswaran, Mia Franulović, Terry K. Judah, , Josephine M. Bryant
This study uses spatial transcriptomics to map Pseudomonas aeruginosa niches in lung tissue from CF and COPD patients, revealing distinct bacterial states and host interactions linked to infection persistence.
bioRxiv · Jul 7, 2026 · PreprintImmunology