Author

Christine Hale

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Alexander V. PredeusiD· 2 shared April Rose FosteriD· 2 shared Bayanne OlabiiD· 2 shared Chloe AdmaneiD· 2 shared Daniela Basurto-LozadaiD· 2 shared David HorsfalliD· 2 shared Emily StephensoniD· 2 shared Gordon DouganiD· 2 shared

Activity by Year

2015-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersDevelopmental Biology

Alexander V. PredeusORCID

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Author profile →

4 papers

Recent·Most cited

An integrated single cell and spatial omics atlas of human prenatal development

Simone Webb, Antony Rose, Chuan Xu, Lloyd Steele, Masami A Kuri, Emily Stephenson, Kemal İnecik, Daniyal J. Jafree, April Rose Foster, Daniela Basurto-Lozada, Nana-Jane Chipampe, Anna Vathrakokoili Pournara, Marc‐Antoine Jacques, Ken To, Chloe Admane, , Muzlifah A. Haniffa

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

bioRxiv · Apr 21, 2026 · PreprintDevelopmental Biology✦ In-depth digest

Hidden immune memory niches in inflammatory skin diseases

Lloyd Steele, April Rose Foster, Kenny Roberts, Chloe Admane, Sebastian Birk, Pavel Mazin, Amir Akbarnejad, Catherine Tudor, Benjamin M. Rumney, Hon Man Chan, Bayanne Olabi, Treasa Jiang, Victoria Rowe, David Baudry, Christine Hale, , Muzlifah A. Haniffa

This study creates a spatially-resolved molecular atlas of human skin and uses deep learning to identify 26 niches, revealing novel immune memory structures in inflammatory skin diseases.

bioRxiv · Mar 23, 2026 · PreprintImmunology

Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune response

Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, Andrew J. Knights, Alice Mann, Kousik Kundu, Christine Hale, Gordon Dougan, Daniel J. Gaffney

The paper identifies genetic effects on chromatin and gene expression in immune response conditions, revealing enhancer priming in naive cells.

Nature Genetics · Jan 29, 2018Peer-reviewedGenomics

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

Kaur Alasoo, Fernando Martinez Estrada, Christine Hale, Siamon Gordon, Fiona Powrie, Gordon Dougan, Subhankar Mukhopadhyay, Daniel Gaffney

The paper compares transcriptomes of macrophages derived from monocytes and iPSCs to identify conserved and novel LPS responses.

bioRxiv · Jun 25, 2015Immunology