Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter
Danielle L. Schmitt, Stephanie D. Curtis, Allen Leung, Jinfan Zhang, Catherine Y. He, Catherine Y. He, Sohum Mehta, Padmini Rangamani, Reuben J. Shaw, Jin Zhang
The paper develops a sensitive AMPK activity reporter, ExRai AMPKAR, to study subcellular AMPK dynamics and reveals differential regulation of AMPK activity at lysosomes, mitochondria, and the nucleus.
Nature Communications · Jul 5, 2022Peer-reviewedMolecular Biology