Allen Leung

Systems modeling of mitochondrial dynamics in different exercise regimes

The paper develops a computational model to simulate how different exercise regimes affect mitochondrial fission and fusion dynamics in skeletal muscle.

Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling

The paper develops a computational model of AMPK and mTOR dynamics in glutamatergic synapses, showing frequency-dependent activation changes and multistability influenced by insulin signaling.

Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter

The paper develops a sensitive AMPK activity reporter, ExRai AMPKAR, to study subcellular AMPK dynamics and reveals differential regulation of AMPK activity at lysosomes, mitochondria, and the nucleus.

Deciphering the postsynaptic calcium-mediated energy homeostasis through mitochondria-endoplasmic reticulum contact sites using systems modeling

The paper develops a 3D reaction-diffusion model to study how mitochondria-endoplasmic reticulum contact sites regulate calcium and ATP dynamics in postsynaptic spines.