NON-REDUNDANT ROLES OF COPPER TRANSPORTERS ATP7A AND ATP7B IN NORADRENERGIC SIGNALING
Shubhrajit Roy, Yu Wang, Susan M. Aja, Niharika Sinha, Andrew M. Crawford, Keith W. MacRenaris, Alexa K. Wade, Kyungdo Kim, Abigael Muchenditsi, Lauryn Torres-Hernandez, Chan-Hyun Na, Anastasia Kralli, Michael J. Petris, Anna J. Taylor, Thomas V. O’Halloran, , Svetlana Lutsenko
This study investigates the distinct roles of ATP7A and ATP7B in noradrenergic signaling, showing they have non-redundant functions in neuronal copper homeostasis and metabolic regulation.
bioRxiv · Jan 16, 2026 · PreprintPhysiology