Chan Hyun Na

This study engineers extracellular vesicles with Syncytin-1 to alter their biodistribution and shows improved persistence and organ targeting in non-human primates.

This study investigates the distinct roles of ATP7A and ATP7B in noradrenergic signaling, showing they have non-redundant functions in neuronal copper homeostasis and metabolic regulation.

The paper identifies molecular programs coordinated with NPTX2 that distinguish cognitive resilience in AD pathology from non-pathological cognition and AD.

The paper analyzes extracellular vesicles from MS and control white matter to identify pathway dysregulation and cellular origin shifts associated with the disease.

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

This study identifies TRIM24's role in ALT telomere maintenance through chromatin signaling, showing it promotes telomere DNA synthesis via SUMO-dependent mechanisms.

The paper identifies potential biomarkers for progressive supranuclear palsy (PSP) in cerebrospinal fluid using proteomics, finding ATP6AP2 as the top performer in distinguishing PSP from Parkinson's Disease and controls.

This paper develops a method for in situ cell-type specific proteome analysis using antibody-mediated biotinylation and validates it on mouse brain tissue.

The paper investigates how energy stress regulates stress-induced ribonucleoprotein granules and identifies key pathways involved in their formation and clearance.

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.

The paper develops a mathematical model combining mRNA splice variants and time-delay to predict protein abundance from RNA-Seq, improving biomarker discovery in immune diseases.