Author

Susan M. Aja

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Dylan C. SarveriD· 2 shared Fangluo CheniD· 2 shared Guang William WongiD· 2 shared Muzna Saqib· 2 shared Abigael Muchenditsi· 1 shared Alexa K. Wade· 1 shared Anastasia Kralli· 1 shared Andrew M. CrawfordiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

Dylan C. SarverORCID

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Author profile →

3 papers

Recent·Most cited

Deep phenotyping and multi-omics analyses reveal systems-wide metabolic dysregulation in a refined trisomy mouse model of Down syndrome

Muzna Saqib, Fangluo Chen, Diya K Mistri, Laura Tan, Noelle Wright, Dylan C. Sarver, Robert A. Anders, Susan M. Aja, Guang William Wong

The paper compares metabolic dysregulation in two Down syndrome mouse models, finding Ts66Yah exhibits more severe metabolic disturbances than Ts65Dn.

bioRxiv · Aug 29, 2026 · PreprintPhysiology

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

Fangluo Chen, Muzna Saqib, Christy M Nguyen, Dylan C. Sarver, Yuejin Eugene Yu, Susan M. Aja, Marcus Michael Seldin, Guang William Wong

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

eLife · Jul 22, 2026Peer-reviewedPhysiology✦ In-depth digest

NON-REDUNDANT ROLES OF COPPER TRANSPORTERS ATP7A AND ATP7B IN NORADRENERGIC SIGNALING

Shubhrajit Roy, Yu Wang, Susan M. Aja, Niharika Sinha, Andrew M. Crawford, Keith W. MacRenaris, Alexa K. Wade, Kyungdo Kim, Abigael Muchenditsi, Lauryn Torres-Hernandez, Chan-Hyun Na, Anastasia Kralli, Michael J. Petris, Anna J. Taylor, Thomas V. O’Halloran, , Svetlana Lutsenko

This study investigates the distinct roles of ATP7A and ATP7B in noradrenergic signaling, showing they have non-redundant functions in neuronal copper homeostasis and metabolic regulation.

bioRxiv · Jan 16, 2026 · PreprintPhysiology