Keith W. MacRenaris

The paper compares Aquamin and calcium carbonate in simulated digestion and colon cell uptake, finding Aquamin more acid-resistant and capable of increasing serum strontium levels.

This paper develops a workflow for high-resolution metal imaging in C. elegans using LA-ICP-TOF-MS, achieving 2-m spatial resolution with optimized embedding and ablation techniques.

The paper demonstrates that using an empirically measured blank spectrum improves the accuracy of quantitative X-ray fluorescence mapping by reducing dependencies on dwell time and spectral aggregation.

The paper functionally screens ZIP8 variants to identify pathogenic mutations and trafficking defects using a combined experimental and computational approach.

This study investigates how material composition and implantation site affect in vivo degradation rates of tissue engineering devices using CT-visible radiopaque composites.

The paper introduces MAGIC MRI, a gene-based reporter system for non-invasive neural tracing in vivo, validated in rodents and rhesus macaques.

This study investigates the distinct roles of ATP7A and ATP7B in noradrenergic signaling, showing they have non-redundant functions in neuronal copper homeostasis and metabolic regulation.

This study shows that AIRE deficiency causes epididymitis and male infertility through immune-mediated fibrosis, iron deposition, and metal imbalance leading to sperm DNA damage.

This study modifies key residues in ZIP8 to alter its metal transport activity and substrate spectrum, identifying variants with enhanced activity and expanded substrate preferences.

AutoSpect automates LA-ICP-TOF-MS data processing, addressing drift correction and peak deconvolution to enable accurate elemental mapping and isotopic analysis.

This paper determines the turnover number of human ZIP4 using stable zinc isotopes and ICP-MS, finding it ranges from 0.08 to 0.2 s-1.