Transgene Expression Kinetics and Replication Potential of Recombinant Adenovirus Serotype 4 in a Mouse Model and its Use as a Herpes Simplex Virus Vaccine
Alexander C Vostal, Dawid Maciorowski, James M. Readler, Isabella S. Pytel, Andy A. Patamawenu, Ceanna Cooney, Peyton M. Roeder, Rachel Roenicke, Freya van't Veer, Tae Kim, Ellison Ober, Yuyan Yi, Jingwen Gu, Mitra Harrison, Breanna Kim, , Jeffrey I. Cohen
This paper evaluates transgene expression and viral replication of recombinant Ad4 in mice, showing protective efficacy against HSV-2 infection.
bioRxiv · May 17, 2026 · PreprintImmunology