The Senescence-Associated Secretory Phenotype constitutes HIF-1α activation but is independent of micronuclei-induced cGas/Sting activation
Celestine Z. Ho, Lin Deng, Remigio Picone, Fieda O. Abderazzaq, Nicole Flanagan, Dominic Zhuohong Chua, Boon Chuan Low, Selwin K. Wu
This study shows that HIF-1α activation defines the SASP across different stressors, independent of micronuclei-induced cGAS/Sting activation.
Molecular Biology of the Cell · Nov 26, 2025Peer-reviewedCell Biology