Fibroblast-derived Collagen VI shapes the structure and function of the tumor-immune microenvironment in clear cell renal cell carcinoma
Maximilian Wess, Grigor Andreev, Tobias Feilen, Nastasja Diel, Max Zirngibl, Constance Gueib-Picard, Anna L. Koessinger, Celia Hinrichs, Andreas Nägel, Clara L. Essmann, Winfried Römer, Martin Helmstädter, Tino Vollmer, Martin Werner, Markus Tobias Grabbert, , Christoph Schell
This study identifies collagen VI as a key ECM component in ccRCC stroma, showing its role in shaping tumor structure, function, and immune response, with implications for TKI therapy.
bioRxiv · Mar 23, 2026 · PreprintCancer Biology