Martin Helmstädter

This study shows that M-CSF drives alveolar macrophage plasticity during development and CMV infection, increasing ISG expression and modulating infection susceptibility.

This study identifies collagen VI as a key ECM component in ccRCC stroma, showing its role in shaping tumor structure, function, and immune response, with implications for TKI therapy.

This study identifies SMAC as a regulator of cancer cell growth, inflammation, and mitochondrial integrity, showing its role in both apoptotic and non-apoptotic contexts.

This study shows that Chlamydia trachomatis uses membrane vesicles to deliver OmpA to mitochondria, inhibiting apoptosis and promoting bacterial survival in human cells.

This study uses cryo-electron tomography to reveal the bi-layered, fishnet-like architecture of the slit diaphragm in Drosophila nephrocytes, linking its structure to function and conservation across species.

This paper establishes a Drosophila model for Dent disease, showing that ClC-c depletion causes Cubilin ER retention and secretory pathway defects, revealing a new pathogenic mechanism.

This study shows ADCK4 deficiency causes CoQ10 deficiency and mitochondrial dysfunction in podocytes, which is rescued by 2,4-dihydroxybenzoic acid treatment.

The paper shows that multiciliated cells can trans-differentiate into secretory cells during developmental remodeling in Xenopus, induced by changes in signaling pathways.