H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment
Fleur Chapus, Christopher R. Day, Laura G. Kammel, Pelin Yaşar, Brian D. Bennett, Erica Scappini, Charles J. Tucker, Maria I. Sifre, Celyn Bregio, Joseph Rodriguez
The paper identifies H3K27me3 chromatin heterogeneity as a mechanism underlying variable TFF1 expression and endocrine resistance in ER+ breast cancer.
bioRxiv · Sep 18, 2025 · PreprintMolecular Biology