Brian D. Bennett

Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells

The paper shows that hormone response magnitude in mammary organoids and ER+ cancer cells varies independently of receptor abundance and follows distinct activation dynamics.

H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment

The paper identifies H3K27me3 chromatin heterogeneity as a mechanism underlying variable TFF1 expression and endocrine resistance in ER+ breast cancer.

Discovery and performance of DNA methylation panels for cancer detection and classification in blood

This paper identifies DNA methylation biomarker panels for multi-cancer detection and tissue-of-origin classification using blood samples, achieving high sensitivity and low false positive rates.

Cnot3 is required for male germ cell development and spermatogonial stem cell maintenance

This study shows that CNOT3 is essential for maintaining spermatogonial stem cells in mice by repressing differentiation factors and regulating the redox pathway.

mRNA stability fine tunes gene expression in the developing cortex to control neurogenesis

The paper shows that RNA stability controls neurogenesis in the developing cortex by regulating gene expression through the CCR4-NOT complex.

Proteasome inhibition reprograms chromatin landscape in breast cancer

This study shows proteasome inhibition changes chromatin accessibility and transcription initiation in breast cancer cells, revealing new insights into how proteasome inhibitors affect gene expression.

INO80 promotes H2A.Z occupancy to regulate 1 cell fate transition in pluripotent stem cells

NF-Y Controls Fidelity of Transcription Initiation at Gene Promoters Through Maintenance of the Nucleosome-Depleted Region

This study shows NF-Y maintains nucleosome-depleted regions at promoters to ensure accurate transcription initiation, preventing aberrant gene expression.

GATA3 mutation disrupts a functional network governed by estrogen receptor, FOXA1 and GATA3

This study investigates how a GATA3 mutation affects the transcriptional network involving ER, FOXA1, and GATA3, showing disrupted cooperation and altered chromatin localization.