Christopher R. Day

Protocol for measuring endocrine disruptive effects on transcriptional bursting using single-molecule imaging in human breast cancer cells

This paper presents a protocol using single-molecule imaging to measure how endocrine disruptors affect transcriptional bursting in human breast cancer cells.

Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells

The paper shows that hormone response magnitude in mammary organoids and ER+ cancer cells varies independently of receptor abundance and follows distinct activation dynamics.

WntA expression and wing transcriptomics illuminate the evolution of stripe patterns in skipper butterflies

This study shows WntA expression and gene expression patterns in skipper butterflies are homologous to the Central Symmetry System in nymphalid butterflies, revealing shared developmental mechanisms for wing stripe patterns.

H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment

The paper identifies H3K27me3 chromatin heterogeneity as a mechanism underlying variable TFF1 expression and endocrine resistance in ER+ breast cancer.

Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies

This study uses single-nucleus transcriptomics to investigate sex-specific gene expression in wing scale cells of Colias eurytheme butterflies, revealing regulatory mechanisms underlying sexual dimorphism.

Frizzled2 receives the WntA morphogen during butterfly wing pattern formation

The paper shows that WntA and Frizzled2 form a signaling axis that instructs butterfly color patterning, with Fz2 acting as a morphogen receptor and other Frizzleds having distinct roles in wing development.