Author

Joseph Rodriguez

National Institute of Environmental Health SciencesORCID 0000-0002-6017-1376Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Christopher R. DayiD· 3 shared Pelin YaşariD· 3 shared Brian D. BennettiD· 2 shared Laura G. KammeliD· 2 shared Celyn Bregio· 1 shared Charles J. TuckeriD· 1 shared Erica ScappiniiD· 1 shared Fleur ChapusiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCell Biology

Christopher R. DayORCID

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Author profile →

3 papers

Recent·Most cited

Protocol for measuring endocrine disruptive effects on transcriptional bursting using single-molecule imaging in human breast cancer cells

Pelin Yaşar, Christopher R. Day, Joseph Rodriguez

This paper presents a protocol using single-molecule imaging to measure how endocrine disruptors affect transcriptional bursting in human breast cancer cells.

STAR Protocols · Sep 1, 2026Peer-reviewedCell Biology

Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells

Pelin Yaşar, Christopher R. Day, Brian D. Bennett, Jackson A. Hoffman, Laura G. Kammel, Trevor Archer, Joseph Rodriguez

The paper shows that hormone response magnitude in mammary organoids and ER+ cancer cells varies independently of receptor abundance and follows distinct activation dynamics.

bioRxiv · Mar 23, 2026 · PreprintCell Biology

H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment

Fleur Chapus, Christopher R. Day, Laura G. Kammel, Pelin Yaşar, Brian D. Bennett, Erica Scappini, Charles J. Tucker, Maria I. Sifre, Celyn Bregio, Joseph Rodriguez

The paper identifies H3K27me3 chromatin heterogeneity as a mechanism underlying variable TFF1 expression and endocrine resistance in ER+ breast cancer.

bioRxiv · Sep 18, 2025 · PreprintMolecular Biology