A platform for deep topographic multiomic mapping of the bone marrow environment in multiple myeloma
Jinsen Lu, Chenyi Wang, Simon Davis, Edmund Watson, Chao Jiang, Warren Baker, Eleanor Calcutt, Sarah Gooding, Joanna Hester, Fadi Issa, Patricia Benevent Bellver, Alessandro Laganà, Chad Bjorklund, Giorgio Napolitani, Sue Griffin, , Srinivasa Rao
The paper develops a spatial tri-omics workflow to map genetically distinct myeloma subclones in bone marrow, showing they occupy spatially and biologically distinct niches.
bioRxiv · Sep 23, 2026 · PreprintCancer Biology