Anjan Thakurta

The paper develops a spatial tri-omics workflow to map genetically distinct myeloma subclones in bone marrow, showing they occupy spatially and biologically distinct niches.

The paper identifies a therapy-driven genomic double-hit (1pCEN LOH and 1q gain) in relapsed/refractory myeloma, associated with poor prognosis and clonal expansion.

The paper identifies early plasma proteomic changes preceding amyloidosis diagnosis, showing cardiac and immune dysregulation before clinical symptoms.

This paper introduces scBUC-seq, a method to correct barcode and UMI errors in single-cell sequencing, enabling direct Nanopore transcriptome sequencing with improved accuracy.