Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA
Sung-Ik Cho, Kayeong Lim, Seongho Hong, Jaesuk Lee, Annie Kim, Chae Jin Lim, Seungmin Ryou, Ji Min Lee, Young Geun Mok, Eugene Chung, Sanghun Kim, Seunghun Han, Sang-Mi Cho, Ji Eun Kim, Eun-Kyoung Kim, , Jin‐Soo Kim
The paper engineers TALE-linked deaminases to reduce off-target edits in mtDNA editing, resulting in mice with Leigh disease mutations and reduced heart rates.
Cell · Jan 1, 2024Peer-reviewedMolecular Biology