Jin‐Soo Kim

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA

The paper engineers TALE-linked deaminases to reduce off-target edits in mtDNA editing, resulting in mice with Leigh disease mutations and reduced heart rates.

FREQUENT GENE CONVERSION IN HUMAN EMBRYOS INDUCED BY DOUBLE STRAND BREAKS

This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.

CRISPR-pass: Gene rescue of nonsense mutations using adenine base editors

CRISPR-pass uses adenine base editors to bypass nonsense mutations in patient-derived fibroblasts, showing potential for treating genetic disorders.

Web-based design and analysis tools for CRISPR base editing

The paper introduces two web tools, BE-Designer and BE-Analyzer, for designing CRISPR base editor targets and analyzing next-generation sequencing data.

Questioning unexpected CRISPR off-target mutations in vivo

The paper questions the claim that unexpected SNVs and indels in CRISPR-treated mice are caused by CRISPR-Cas9, highlighting the lack of validation for these off-target effects.