Molecular BiologyCellPeer-reviewed
Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA
Sung-Ik Cho, Kayeong Lim, Seongho Hong…·Jin‐Soo Kim
The paper engineers TALE-linked deaminases to reduce off-target edits in mtDNA editing, resulting in mice with Leigh disease mutations and reduced heart rates.