The lateral entorhinal cortex is a hub for local and global dysfunction in pre-tauopathy states
Francesca Mandino, Ling Yun Yeow, Renzhe Bi, Lee Sejin, Han‐Gyu Bae, Seung Hyun Baek, Chun-Yao Lee, Hasan Mohammad, Chai Lean Teoh, Corey L. Horien, Jasinda H. Lee, Mitchell K.P. Lai, Sangyong Jung, Yu Fu, Malini Olivo, , Joanes Grandjean
This study identifies a dichotomic hypo-connected resting and hyper-responsive active phenotype in a mouse model of early tauopathy, with implications for Alzheimer's disease.
bioRxiv · Apr 3, 2020 · PreprintNeuroscience